Progress in Establishment of Endometriosis in Vitro Histological Models

Ma Di

doi:doi:10.11648/j.sd.20180606.37

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Progress in Establishment of Endometriosis in Vitro Histological Models

Ma Di

Published in Science Discovery (Volume 6, Issue 6)

Received: 26 December 2018 Published: 27 December 2018

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Abstract

The etiology and pathogenesis of endometriosis are hotspots in the field of obstetrics and gynecology today.With the rapid development of experimental studies of endometriosis, the establishment of in vitro histological models is increasingly important.The establishment and application of in vitro histological model provides a new research platform for exploring the pathogenesis and treatment of endometriosis. It is an important method to study endometriosis. Recently a variety of models have been successfully constructed, but still have many deficiencies. Up to now, studies on in vitro histological models have been qualitative, and no studies have involved quantitative analysis. Whether peritoneal mesothelial defect is the cause or result of adhesion, that is, peritoneal mesothelial defect itself exists in the patient, or the damage of the mesothelial during operation, or the destruction of the mesothelial by some cytokines secreted by implanted endometrial tissue? These problems have not yet been decided. Therefore, the choice of appropriate histological model to establish a method is conducive to further reveal the etiology of endometriosis, pathogenesis and evaluation of treatment. This paper reviews the research progress about the development of endometriosis with establishment of in vitro histological models, to further explore the best and stable culture conditions of human endometriosis histological model, and to establish a good model basis for further study of endometriosis.

Published in	Science Discovery (Volume 6, Issue 6)
DOI	10.11648/j.sd.20180606.37
Page(s)	551-554
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Endometriosis, Establishment of Vitro Histological Models, Research Progress

References

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APA Style

Ma Di. (2018). Progress in Establishment of Endometriosis in Vitro Histological Models. Science Discovery, 6(6), 551-554. https://doi.org/10.11648/j.sd.20180606.37

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ACS Style

Ma Di. Progress in Establishment of Endometriosis in Vitro Histological Models. Sci. Discov. 2018, 6(6), 551-554. doi: 10.11648/j.sd.20180606.37

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AMA Style

Ma Di. Progress in Establishment of Endometriosis in Vitro Histological Models. Sci Discov. 2018;6(6):551-554. doi: 10.11648/j.sd.20180606.37

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@article{10.11648/j.sd.20180606.37,
  author = {Ma Di},
  title = {Progress in Establishment of Endometriosis in Vitro Histological Models},
  journal = {Science Discovery},
  volume = {6},
  number = {6},
  pages = {551-554},
  doi = {10.11648/j.sd.20180606.37},
  url = {https://doi.org/10.11648/j.sd.20180606.37},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20180606.37},
  abstract = {The etiology and pathogenesis of endometriosis are hotspots in the field of obstetrics and gynecology today.With the rapid development of experimental studies of endometriosis, the establishment of in vitro histological models is increasingly important.The establishment and application of in vitro histological model provides a new research platform for exploring the pathogenesis and treatment of endometriosis. It is an important method to study endometriosis. Recently a variety of models have been successfully constructed, but still have many deficiencies. Up to now, studies on in vitro histological models have been qualitative, and no studies have involved quantitative analysis. Whether peritoneal mesothelial defect is the cause or result of adhesion, that is, peritoneal mesothelial defect itself exists in the patient, or the damage of the mesothelial during operation, or the destruction of the mesothelial by some cytokines secreted by implanted endometrial tissue? These problems have not yet been decided. Therefore, the choice of appropriate histological model to establish a method is conducive to further reveal the etiology of endometriosis, pathogenesis and evaluation of treatment. This paper reviews the research progress about the development of endometriosis with establishment of in vitro histological models, to further explore the best and stable culture conditions of human endometriosis histological model, and to establish a good model basis for further study of endometriosis.},
 year = {2018}
}

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TY  - JOUR
T1  - Progress in Establishment of Endometriosis in Vitro Histological Models
AU  - Ma Di
Y1  - 2018/12/27
PY  - 2018
N1  - https://doi.org/10.11648/j.sd.20180606.37
DO  - 10.11648/j.sd.20180606.37
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 551
EP  - 554
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20180606.37
AB  - The etiology and pathogenesis of endometriosis are hotspots in the field of obstetrics and gynecology today.With the rapid development of experimental studies of endometriosis, the establishment of in vitro histological models is increasingly important.The establishment and application of in vitro histological model provides a new research platform for exploring the pathogenesis and treatment of endometriosis. It is an important method to study endometriosis. Recently a variety of models have been successfully constructed, but still have many deficiencies. Up to now, studies on in vitro histological models have been qualitative, and no studies have involved quantitative analysis. Whether peritoneal mesothelial defect is the cause or result of adhesion, that is, peritoneal mesothelial defect itself exists in the patient, or the damage of the mesothelial during operation, or the destruction of the mesothelial by some cytokines secreted by implanted endometrial tissue? These problems have not yet been decided. Therefore, the choice of appropriate histological model to establish a method is conducive to further reveal the etiology of endometriosis, pathogenesis and evaluation of treatment. This paper reviews the research progress about the development of endometriosis with establishment of in vitro histological models, to further explore the best and stable culture conditions of human endometriosis histological model, and to establish a good model basis for further study of endometriosis.
VL  - 6
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Author Information

Ma Di

Obstetrics and Gynecology Department, First Affiliated Hospital of Harbin Medical University, Harbin, China

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APA Style

Ma Di. (2018). Progress in Establishment of Endometriosis in Vitro Histological Models. Science Discovery, 6(6), 551-554. https://doi.org/10.11648/j.sd.20180606.37

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ACS Style

Ma Di. Progress in Establishment of Endometriosis in Vitro Histological Models. Sci. Discov. 2018, 6(6), 551-554. doi: 10.11648/j.sd.20180606.37

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AMA Style

Ma Di. Progress in Establishment of Endometriosis in Vitro Histological Models. Sci Discov. 2018;6(6):551-554. doi: 10.11648/j.sd.20180606.37

Copy | Download

@article{10.11648/j.sd.20180606.37,
  author = {Ma Di},
  title = {Progress in Establishment of Endometriosis in Vitro Histological Models},
  journal = {Science Discovery},
  volume = {6},
  number = {6},
  pages = {551-554},
  doi = {10.11648/j.sd.20180606.37},
  url = {https://doi.org/10.11648/j.sd.20180606.37},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20180606.37},
  abstract = {The etiology and pathogenesis of endometriosis are hotspots in the field of obstetrics and gynecology today.With the rapid development of experimental studies of endometriosis, the establishment of in vitro histological models is increasingly important.The establishment and application of in vitro histological model provides a new research platform for exploring the pathogenesis and treatment of endometriosis. It is an important method to study endometriosis. Recently a variety of models have been successfully constructed, but still have many deficiencies. Up to now, studies on in vitro histological models have been qualitative, and no studies have involved quantitative analysis. Whether peritoneal mesothelial defect is the cause or result of adhesion, that is, peritoneal mesothelial defect itself exists in the patient, or the damage of the mesothelial during operation, or the destruction of the mesothelial by some cytokines secreted by implanted endometrial tissue? These problems have not yet been decided. Therefore, the choice of appropriate histological model to establish a method is conducive to further reveal the etiology of endometriosis, pathogenesis and evaluation of treatment. This paper reviews the research progress about the development of endometriosis with establishment of in vitro histological models, to further explore the best and stable culture conditions of human endometriosis histological model, and to establish a good model basis for further study of endometriosis.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Progress in Establishment of Endometriosis in Vitro Histological Models
AU  - Ma Di
Y1  - 2018/12/27
PY  - 2018
N1  - https://doi.org/10.11648/j.sd.20180606.37
DO  - 10.11648/j.sd.20180606.37
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 551
EP  - 554
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20180606.37
AB  - The etiology and pathogenesis of endometriosis are hotspots in the field of obstetrics and gynecology today.With the rapid development of experimental studies of endometriosis, the establishment of in vitro histological models is increasingly important.The establishment and application of in vitro histological model provides a new research platform for exploring the pathogenesis and treatment of endometriosis. It is an important method to study endometriosis. Recently a variety of models have been successfully constructed, but still have many deficiencies. Up to now, studies on in vitro histological models have been qualitative, and no studies have involved quantitative analysis. Whether peritoneal mesothelial defect is the cause or result of adhesion, that is, peritoneal mesothelial defect itself exists in the patient, or the damage of the mesothelial during operation, or the destruction of the mesothelial by some cytokines secreted by implanted endometrial tissue? These problems have not yet been decided. Therefore, the choice of appropriate histological model to establish a method is conducive to further reveal the etiology of endometriosis, pathogenesis and evaluation of treatment. This paper reviews the research progress about the development of endometriosis with establishment of in vitro histological models, to further explore the best and stable culture conditions of human endometriosis histological model, and to establish a good model basis for further study of endometriosis.
VL  - 6
IS  - 6
ER  -

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